Phenformin overdose.
نویسندگان
چکیده
منابع مشابه
Fatal lactic acidosis after an overdose of phenformin.
The patient; a 64-year-old housewife, had been known to suffer from maturity-onset diabetes for four years. She was treated with chlorpropamide for 18 months, and then with a 1,000-calorie diet (130 g. of carbohydrate) alone for three months. She remained more than a stone (6.4 kg.) above the standard weight for her height and was therefore started on phenformin in May 1964 in order to treat he...
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Since 1956 biguanides have received attention as oral hypoglycaemic agents (Krall and Bradley, 1959). Ungar, Madison, and Carter (1960), using phenformin (Dibotin, phenethyl biguanide), showed their effect on peripheral utilization of glucose, Butterfield, Fry, and Holling (1958) having previously demonstrated increased uptake of insulin in hepatic and peripheral tissues. Since then the drug ha...
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Thirty-eight patients who presented with diabetes and a changed state of consciousness satisfied the criteria for lactic acidosis. Sixteen patients were non-ketotic, and 15 of these were receiving phenformin on admission. In all but one of these 15 patients, however, additional renal or cardiovascular abnormalities, or both, could be identified, which supported a multifactorial aetiology for la...
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Two cases with clinical signs ofpulmonary hypertension and right heart failure developing during phenformin treatment are reported. The patients were clinically improved on withdrawal of phenformin. Two possible explanations for the pulmonary hypertension were considered: cellular anaerobiosis or alphareceptor stimulation of the pulmonary vessels. The 4 patients sofar reported direct attention ...
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sociated with albuminuria in type 2 diabetic patients (4). To the best of our knowledge, however, it is not clear whether serum homocysteine is associated with TNF receptor in type 2 diabetic patients. The aim of the present study was therefore to investigate the relationships between serum homocysteine and TNF receptor in patients with type 2 diabetes. Fifty nonobese Japanese type 2 diabetic p...
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ژورنال
عنوان ژورنال: BMJ
سال: 1972
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5792.112-b